During the first PRF Asia-Pacific webinar, on October 29, 2019, Fumimasa Amaya, MD, PhD, Kyoto Prefectural University of Medicine, Japan, discussed the role of mitochondrial dysfunction in painful diabetic neuropathy. After his talk, there was a question-and-answer period moderated by Ru-Rong Ji, PhD, Duke University Medical Center, US.
- Fumimasa Amaya, MD, PhD, Kyoto Prefectural University of Medicine, Japan
- Ru-Rong Ji, PhD, Duke University Medical Center, Durham, US
Listen to the webinar below.
Here is an abstract of Dr. Amaya’s talk:
Mitochondria are one of the important intracellular organelles responsive to the production of ATP. Mitochondria exist abundantly in neuronal cells as an energy source of neuronal activity, such as synaptic transmission, axonal transport, and protein synthesis. Mitochondrial quality is tightly regulated by the autophagocytosis of damaged mitochondria. Disruption of mitochondrial quality control is a common pathological change observed in diabetes and neurodegenerative diseases. Dr. Amaya will demonstrate the biological significance of mitochondrial dysfunction in DRG neurons and its association with the development of painful diabetic neuropathy. He will highlight the role of p53 and parkin for the regulation of mitochondrial quality control.
Want some background reading? See the recent papers under Related Content in the right column of this page. And join the conversation about the webinar on Twitter @PainResForum #PRFWebinar
See previous PRF webinars here.