Browse by Audience
Skip to content
Papers of the Week
Pregabalin inhibits purinergic P2Y receptor and TRPV4 to suppress astrocyte activation and to relieve neuropathic pain.
Authors
Song S, Wang Q, Qu Y, Gao W, Li D, Xu X, Yue SAbstract
Transient receptor potential vanilloid 4 (TRPV4)-mediated astrocyte activation is critical to neuropathic pain. Pregabalin, a widely used drug to treat chronic pain, is reported to lower the intracellular calcium level. However, the molecular mechanism by which pregabalin decreases the intracellular calcium level remains unknown. Purinergic P2Y receptor-a member of the G protein-coupled receptor (GPCR) family-regulates calcium-related signal transduction in astrocyte activation. We investigated whether P2Y receptor is involved in the pharmacological effects of pregabalin on neuropathic pain.